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KMID : 1128320160140020021
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Electrolytes & Blood Pressure
2016 Volume.14 No. 2 p.21 ~ p.26
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Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension
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Lee Yu-Ho
Kim Yang-Gyun
Moon Ju-Young
Kim Jin-Sug
Jeong Kyung-Hwan
Lee Tae-Won
Ihm Chun-Gyoo
Lee Sang-Ho
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Abstract
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One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of TH and hypertension.
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KEYWORD
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Tyrosine hydroxylase, Hypertension, Single nucleotide polymorphism
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